By Magdalena Szczerbowska-Boruchowska (auth.), M.A. Hayat (eds.)
As relating to its 11 predecessors within the sequence Tumors of the imperative anxious procedure, this quantity is wonderful for its thorough technique, its roster of ninety two exotic individuals representing eleven varied nations and its exact exam of modern expertise and techniques.
Volume 12: Molecular Mechanisms, Children’s melanoma, remedies, and Radiosurgery deals a entire overview of the prognosis, treatment and diagnosis of mind and spinal wire tumors. assurance extends to loads of tumor kinds, together with neuroblastoma, medulloblastoma, meningioma and chordoma. Molecular profiling of mind tumors to choose acceptable remedy in scientific trials of mind tumors is mentioned intimately, as is the classification/diagnosis of mind tumors in keeping with functionality research. CDK6 because the molecular regulator of neuronal differentiation within the grownup mind, and the position of aquaporins in human mind tumor progress are defined. dialogue additionally comprises tumors affecting youngsters, together with neuroblastoma and medulloblastoma. an entire bankruptcy is dedicated to the position of molecular genetic changes in medulloblastoma, and one other examines survival changes among young ones and adults with medulloblastoma. using numerous varieties of imaging the right way to diagnose mind tumors is defined. In-depth dialogue of remedies contains stereotactic radiosurgery, endoscopic neurosurgery, electrochemotherapy, transsphenoidal surgical procedure, focal ablation, entire mind radiation treatment and recraniotomy.
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Additional resources for Tumors of the Central Nervous System, Volume 12: Molecular Mechanisms, Children's Cancer, Treatments, and Radiosurgery
All of them are important from a medical point of view (Negendank 1992). The 31P-MRS may assist tumor diagnosis by the studies of energy metabolism as the content of phosphocreatine, adenosine5′-triphosphate (ATP) and inorganic phosphate can be determined. Moreover, phosphomonoesters, which level was found to be increased in tumors in compare with normal tissue, can be followed using the 31P-MRS. It should be also mentioned that this technique allows for the calculation of intracellular pH, which is an important parameter in the study of neoplastic tissues.
Stark Department of Neurosurgery, Schleswig Holstein University Medical Center, Kiel, Germany Magdalena Szczerbowska-Boruchowska Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Krakow, Poland Satoshi Takahashi Department of Neurosurgery and Neurology, ChariteUniversity Medicine, Campus Virchow Clinic, Berlin, Germany Giuseppe Talamonti Department of Neurosurgery, Niguarda Ca’Granda Hospital, Milan, Italy xlviii Lucie M. Turcotte University of Minnesota, Minneapolis, MN, USA A.
Moreover, nothing is directly given in a microscopic picture of the tumor sample. In many cases evaluation and histopathological diagnosis are at variance. Probably, oligodendroglial tumors are among the most susceptible with regard to the differences in neuropathological interpretation and prognostication (Giannini et al. 2008). , non-neoplastic glial reaction and low grade astrocytoma should to be mentioned (Burger and Scheithauer 2007). Routinely, hematoxylin-eosin (HE) staining of tissue samples embedded in paraffin is used for histopathological examination.
Tumors of the Central Nervous System, Volume 12: Molecular Mechanisms, Children's Cancer, Treatments, and Radiosurgery by Magdalena Szczerbowska-Boruchowska (auth.), M.A. Hayat (eds.)