By Andreas Marneros, Hagop S. Akiskal
Many clinicians and researchers are confident that there's an overlap among affective and schizophrenic spectra. during this ebook, a world group of specialists talk about features of comorbidity, genetic types, scientific direction, phenomenology and treatments. this can be the 1st entire evaluate of the schizoaffective spectra. difficult circumstances featuring scientific and paraclinical gains of either spectra are unusually a variety of. not just the phenomenology but in addition the direction, end result and therapy of such instances have their very own features. fresh study exhibits that the overlap additionally comprises genetics and organic techniques concerning psychotic problems. in the overlap of affective and schizophrenic spectra it really is attainable to spot a few teams of problems having related medical and non-clinical beneficial properties: the 'schizoaffective' crew, 'Acute and brief Psychotic sickness' or 'Brief Psychosis', and different teams present in so-called 'Atypical Forms'.
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Extra resources for The Overlap of Affective and Schizophrenic Spectra
Berlin, Heidelberg, New York: Springer, pp. 107–26. , and Robins, E. (1977). The group of schizoaﬀective and related psychoses: A follow-up study. Comprehensive Psychiatry, 18, 413–22. , Welner, Z. and Fishman, R. (1979). The group of schizoaﬀective and related psychoses: IV. A family study. Comprehensive Psychiatry, 20, 21–5. Wernicke, C. (1900). Grundriss der Psychiatrie. Leipzig: Thieme. Wing, J. , Cooper, J. E. and Sartorius, N. (1974). The Measurement and Classiﬁcation of Psychiatric Symptoms.
But neither are they a group of a so-called schizophrenic spectrum, whatever this means. There is also no reliable deﬁnition of the elastic and changeable schizophrenic spectrum (Andreasen and Flaum, 1995), nor is there a reliable deﬁnition of the elastic and changeable “aﬀective spectrum” (Akiskal and Pinto, 2000). If we accept continuity between the various psychotic groups – but not only between them – then the position of the Brief Polymorphic Psychosis is obviously a position within the spectrum of the psychotic continuum.
The most compelling data come from the recent identiﬁcation of genes for each disorder. Though this is at an early stage and only a few genes have been identiﬁed with promising data, several of them show evidence of association to both disorders. If a substantial portion of the genes for these disorders is shared, then one must ask, what is it that distinguishes between these two illnesses? 2. One possibility is that of allelic heterogeneity. Diﬀerent mutations in the same gene may disrupt gene and protein function in diﬀerent ways and lead to diﬀerent phenotypes.
The Overlap of Affective and Schizophrenic Spectra by Andreas Marneros, Hagop S. Akiskal