Download e-book for iPad: The Overlap of Affective and Schizophrenic Spectra by Andreas Marneros, Hagop S. Akiskal

By Andreas Marneros, Hagop S. Akiskal

ISBN-10: 051127016X

ISBN-13: 9780511270161

ISBN-10: 0521858585

ISBN-13: 9780521858588

Many clinicians and researchers are confident that there's an overlap among affective and schizophrenic spectra. during this ebook, a world group of specialists talk about features of comorbidity, genetic types, scientific direction, phenomenology and treatments. this can be the 1st entire evaluate of the schizoaffective spectra. difficult circumstances featuring scientific and paraclinical gains of either spectra are unusually a variety of. not just the phenomenology but in addition the direction, end result and therapy of such instances have their very own features. fresh study exhibits that the overlap additionally comprises genetics and organic techniques concerning psychotic problems. in the overlap of affective and schizophrenic spectra it really is attainable to spot a few teams of problems having related medical and non-clinical beneficial properties: the 'schizoaffective' crew, 'Acute and brief Psychotic sickness' or 'Brief Psychosis', and different teams present in so-called 'Atypical Forms'.

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Extra resources for The Overlap of Affective and Schizophrenic Spectra

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Berlin, Heidelberg, New York: Springer, pp. 107–26. , and Robins, E. (1977). The group of schizoaffective and related psychoses: A follow-up study. Comprehensive Psychiatry, 18, 413–22. , Welner, Z. and Fishman, R. (1979). The group of schizoaffective and related psychoses: IV. A family study. Comprehensive Psychiatry, 20, 21–5. Wernicke, C. (1900). Grundriss der Psychiatrie. Leipzig: Thieme. Wing, J. , Cooper, J. E. and Sartorius, N. (1974). The Measurement and Classification of Psychiatric Symptoms.

But neither are they a group of a so-called schizophrenic spectrum, whatever this means. There is also no reliable definition of the elastic and changeable schizophrenic spectrum (Andreasen and Flaum, 1995), nor is there a reliable definition of the elastic and changeable “affective spectrum” (Akiskal and Pinto, 2000). If we accept continuity between the various psychotic groups – but not only between them – then the position of the Brief Polymorphic Psychosis is obviously a position within the spectrum of the psychotic continuum.

The most compelling data come from the recent identification of genes for each disorder. Though this is at an early stage and only a few genes have been identified with promising data, several of them show evidence of association to both disorders. If a substantial portion of the genes for these disorders is shared, then one must ask, what is it that distinguishes between these two illnesses? 2. One possibility is that of allelic heterogeneity. Different mutations in the same gene may disrupt gene and protein function in different ways and lead to different phenotypes.

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The Overlap of Affective and Schizophrenic Spectra by Andreas Marneros, Hagop S. Akiskal


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