The Liver in Systemic Diseases by Hiromasa Ohira PDF

By Hiromasa Ohira

ISBN-10: 443155789X

ISBN-13: 9784431557890

ISBN-10: 4431557903

ISBN-13: 9784431557906

Based at the result of reports on autoimmunity, the endocrine process, meals, steel metabolism and intestinal bacterial plants, this quantity completely covers reports on useful correlation of the liver with the spleen, visceral fats, intestinal tract, and principal anxious approach. together with institutions with dysbiosis, nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma, it deals complete info on correlations of organs with the liver from uncomplicated and scientific viewpoints. The Liver in Systemic Diseases will particularly be of curiosity to researchers, scientific citizens and scientific scholars with an curiosity in hepatology and gastroenterology. moreover, the e-book has interdisciplinary charm and gives a beginning that might aid physicians to think about medical stipulations of illnesses from a broader perspective.

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Get The Liver in Systemic Diseases PDF

In accordance with the result of experiences on autoimmunity, the endocrine approach, foodstuff, steel metabolism and intestinal bacterial flowers, this quantity completely covers stories on useful correlation of the liver with the spleen, visceral fats, intestinal tract, and significant fearful procedure. together with institutions with dysbiosis, nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma, it bargains complete info on correlations of organs with the liver from simple and medical viewpoints.

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3 NAFLD/NASH Nonalcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance (IR), and type 2 diabetes. NAFLD is a hepatic manifestation of metabolic syndrome and is thought to progress to nonalcoholic steatohepatitis (NASH) in about 10 % of patients, with a potential to develop into cirrhosis and even hepatocellular carcinoma (HCC) [5]. Although the pathogenesis of NAFLD has not been fully elucidated, the “two-hit” theory has been proposed to explain its development. The “first hit” involves hepatic lipid accumulation due to IR [6], which is followed by the “second hit” characterized by oxidative stress, leading to lipid peroxidation, secretion of pro-inflammatory cytokines such as tumor necrosis factor α and adipokines, and mitochondrial dysfunction.

Abrogation of the antifibrotic effects of natural killer cells/ interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gastroenterology. 2008;134:248–58. 83. Yu L-X, Yan H-X, Liu Q, Yang W, Wu H-P, Dong W, et al. Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents. Hepatology. 2010;52:1322–33. 84. Dapito DH, Mencin A, Gwak G-Y, Pradere J-P, Jang M-K, Mederacke I, et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4.

Fan Q, Jing Y, Yu G, Kou X, Ye F, Gao L, et al. Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial – mesenchymal transition in hepatocellular carcinoma. Cancer Lett. 2014;352:160–8. 86. Mertens JC, Fingas CD, Christensen JD, Smoot RL, Bronk SF, Werneburg NW, et al. Therapeutic effects of deleting cancer-associated fibroblasts in cholangiocarcinoma. Cancer Res. 2013;73:897–907. 87. Eiro N, Altadill A, Jua´rez LM, Rodrı´guez M, Gonza´lez LO, Atienza S, et al.

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