Download e-book for iPad: Taste and Smell by Dietmar Krautwurst (eds.)

By Dietmar Krautwurst (eds.)

ISBN-10: 3319489259

ISBN-13: 9783319489254

ISBN-10: 3319489275

ISBN-13: 9783319489278

Medicinal chemistry is either technological know-how and paintings. The technological know-how of medicinal chemistry bargains mankind one in all its most sensible hopes for bettering the standard of lifestyles. The artwork of medicinal chemistry keeps to problem its practitioners with the necessity for either instinct and adventure to find new medications. consequently sharing the adventure of drug study is uniquely valuable to the sector of medicinal chemistry. Drug study calls for interdisciplinary team-work on the interface among chemistry, biology and drugs. accordingly, the topic-related sequence subject matters in Medicinal Chemistry covers all suitable features of drug study, e.g. pathobiochemistry of ailments, id and validation of (emerging) drug ambitions, structural biology, drugability of ambitions, drug layout methods, chemogenomics, artificial chemistry together with combinatorial equipment, bioorganic chemistry, typical compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions at the molecular point, structure-activity relationships, drug absorption, distribution, metabolism, removing, toxicology and pharmacogenomics. in most cases, specified volumes are edited through popular visitor editors.

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Extra info for Taste and Smell

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Sutherland K, Young RL, Cooper NJ, Horowitz M, Blackshaw LA (2007) Phenotypic characterization of taste cells of the mouse small intestine. Am J Physiol Gastrointest Liver Physiol 292(5):G1420–G1428 24. Wu SV, Chen MC, Rozengurt E (2005) Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat. Physiol Genomics 22(2):139–149 26 M. Behrens et al. 25. Wu SV, Rozengurt N, Yang M, Young SH, Sinnett-Smith J, Rozengurt E (2002) Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells.

J Biol Chem 288(45):32475–32489. 514034 56. Lund TC, Kobs AJ, Kramer A, Nyquist M, Kuroki MT, Osborn J, Lidke DS, Low-Nam ST, Blazar BR, Tolar J (2013) Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression. PLoS One 8(3):e58945. doi:10. 0058945 57. Wauson EM, Zaganjor E, Lee AY, Guerra ML, Ghosh AB, Bookout AL, Chambers CP, Jivan A, McGlynn K, Hutchison MR, Deberardinis RJ, Cobb MH (2012) The G proteincoupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy.

034 46. Cong WN, Wang R, Cai H, Daimon CM, Scheibye-Knudsen M, Bohr VA, Turkin R, Wood WH 3rd, Becker KG, Moaddel R, Maudsley S, Martin B (2013) Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice. PLoS One 8(8):e70257. 0070257 47. Dehkordi O, Rose JE, Fatemi M, Allard JS, Balan KV, Young JK, Fatima S, Millis RM, Jayam-Trouth A (2012) Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem. Brain Res 1475:1–10.

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