Stratum Corneum by H. P. Baden, J. Kubilus (auth.), Professor Ronald Marks, PDF

By H. P. Baden, J. Kubilus (auth.), Professor Ronald Marks, Professor Dr. Gerd Plewig (eds.)

ISBN-10: 3540117040

ISBN-13: 9783540117049

ISBN-10: 3642686826

ISBN-13: 9783642686825

The stratum corneum is an impressive instance of the profitable edition of a tissue. Its effective functionality is a prerequisite for all times itself. we rely on its regulate of the circulation of water in the course of the epidermis and on its protecting position within the prevention of penetration via pathogens or destructive components. except its practical value, there's no escaping the truth that the commonest epidermis issues (psoriasis, eczema, inherited issues of keratinization, zits) are 'characterised via irregular keratinization and or scaliness. regardless of all this, knowing of its chemistry, constitution, body structure and involvement in illness has been unfortunately poor; even if, there are indicators of enlightenment. This symposium is proof of replaced atti· tudes. best researchers from many nations have utilized modem biomedical strategies and the equipment of molecular biology to the various difficulties and questions posed by means of the stratum corneum. even if there were numerous symposia and guides at the strategy of keratinization, few were generally according to the stratum corneum. hence we think that the complaints of this symposium should be valuable for all who're profeSSionally focused on epidermis biology. Cardiff/Diisseldorf, November 1982 R. Marks G. Plewig v Acknowledgements Alcon Labs. restricted Brocades G. B. restricted Cardiff urban Council Cassella-Riedel Pharma GmbH. Cilag-Chemie Dermal Laboratories constrained Dista items constrained Dome Div. Miles Laboratories constrained Hoechst AG. Imperial Chemical Industries restricted Janssen prescribed drugs restricted Johnson & Johnson restricted L'Oreal E.

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These properties also closely resemble those of the keratin complex of the stratum corneum. 36 References 1. Abernathy JL, Hill RL, Goldsmith LA (1977) e-(-y-Glutamyl)lysine cross-links in human stratum corneum. J BioI Chern 252:1837-1839 2. Baden HP, Lee LD (1978) Fibrous proteins of human epidennis. JInvest Dennatol71: 148-151 3. Baden HP, Lee LD, Kubilus J (1976) The fibrous protein of stratum corneum. J Invest DennatoI67:573-576 4. Ball RD, Walker GK, Bernstein IA (1978) Histidine-rich proteins as molecular markers of epidermal differentiation.

Academic Press, London, pp 126-166 28. Steinert PM, Gullino MI (1976) Bovine epidermal keratin filament assembly in vitro. Biochem Biophys Res Commun 70:221-227 29. Steinert PM, Idler WW (1975) The polypeptide composition of bovine epidermal a-keratin. BiochemI151:603-614 30. Steinert PM, Idler WW (1979) Postsynthetic modifications of mammalian epidermal a-keratin. Biochemistry 18:5264-5669 3l. Steinert PM, Yuspa SH (1978) Biochemical evidence for keratinization by mouse epidermal cells in culture.

The terminal differentiation of epidermal cells can be studied in culture, and this chapter describes one stage in the process: the synthesis of involucrin, an envelope precursor protein. For an extensive review of other aspects of keratinocyte differentiation the reader is referred to Green [7]. Cell Culture Several years ago, James Rheinwald and Howard Green developed a system for culturing cells of stratified squamous epithelia under conditions in which they retained many of their differentiated functions [11 J.

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Stratum Corneum by H. P. Baden, J. Kubilus (auth.), Professor Ronald Marks, Professor Dr. Gerd Plewig (eds.)


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