By Colm McDonald; European Foundation for Psychiatry at the Maudsley.; European Foundation for Psychiatry at the Maudsley. Meeting; et al
This booklet makes a speciality of significant present concerns within the aetiology, pathogenesis and remedy of schizophrenia, and significantly analyses the facts aiding the various traditional reviews concerning the disease.
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Extra info for Schizophrenia : challenging the orthodox
At this stage 373 more patients were included for association analysis. The refined haplotype analysis revealed that the at-risk haplotype sat right on top of two genes, the neuregulin 1 gene Schizophrenia: Challenging the orthodox 22 and a cluster of expressed sequence tags (EST) with unknown function. The work then proceeded to sequence the mouse locus in order to help identify exons and promoter regions. Twenty-five exons were found in the neuregulin 1 gene, some of these were novel and eight exons were found for the EST cluster.
Am J Psychiatry 1996; 153:1534–1540. 3. Levinson DF, Wildenauer DB, Schwab SG et al, Additional support for schizophrenia linkage on chromosomes 6 and 8: a multicenter study. Am J Med Genet 1996; 67:580–594. Genes for schizophrenia can be detected—data from Iceland implicates neuregulin 1 25 4. Blouin JL, Dombroski BA, Nath SK et al, Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 1998; 20:70–73. 5. Kaufmann CA, Suarez B, Malaspina D et al, NIMH genetics initiative millennium schizophrenia consortium: linkage analysis of African-American pedigrees.
Int J Psychiatry Clin Pract 2001; 5:71–73. 7. Mata I, Madoz V, Arranz MJ, Sham P, Murray RM, Olanzapine: concordant response in monozygotic twins with schizophrenia. Br J Psychiatry 2001; 178:86. 8. Vojvoda D, Grimmell K, Sernyak M, Mazure CM, Monozygotic twins concordant for response to clozapine. Lancet 1996; 347:61. 9. Weber WW, Pharmacogenetics. Oxford University Press: Oxford, 1997. 10. Ellenbroek BA, Cools AR, Atypical Antipsychotics. Milestones in Drug Therapy. Verlag AG, Publ: Birkhäuser, 2000.
Schizophrenia : challenging the orthodox by Colm McDonald; European Foundation for Psychiatry at the Maudsley.; European Foundation for Psychiatry at the Maudsley. Meeting; et al