Read e-book online RGS protein physiology and pathophysiology PDF

By Rory A. Fisher

ISBN-10: 0128029382

ISBN-13: 9780128029381

RGS Protein body structure and Pathophysiology describes the present, cutting-edge study happening within the laboratories of leaders within the RGS protein box that make the most of genetic mouse versions to interrogate the functionality of RGS proteins in vivo.

Each bankruptcy describes the elucidated position of a particular RGS protein or family members of RGS proteins in general body structure and/or illness with specific emphasis on how those discoveries tell healthcare and drug discovery.

The paintings is a well timed reference as medicines concentrating on G protein coupled receptors characterize forty% of presently advertised therapeutics.

  • Brings jointly details at the present country of the RGS protein field
  • Contains entire descriptions of the identified pathophysiological and physiological services of RGS proteins, the 1st such undertaking
  • Gives specific emphasis to the methods those discoveries tell healthcare and drug discovery

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RGS inhibition at G(alpha)i2 selectively potentiates 5-HT1A-mediated antidepressant effects. Proc Natl Acad Sci U S A. 2010;107(24):11086–11091. 29. Waterson RE, Thompson CG, Mabe NW, et al. Galpha(i2)-mediated protection from ischaemic injury is modulated by endogenous RGS proteins in the mouse heart. Cardiovasc Res. 2011;91(1):45–52. 30. Kaur K, Parra S, Chen R, et al. Galphai2 signaling: friend or foe in cardiac injury and heart failure? Naunyn Schmiedebergs Arch Pharmacol. 2012;385(5):443–453.

Miki N, Keirns JJ, Marcus FR, Freeman J, Bitensky MW. Regulation of cyclic nucleotide concentrations in photoreceptors: an ATP-dependent stimulation of cyclic nucleotide phosphodiesterase by light. Proc Natl Acad Sci USA. 1973;70(12):3820–3824. 4. Hagins WA. The visual process: excitatory mechanisms in the primary receptor cells. Annu Rev Biophys Bioeng. 1972;1:131–158. 5. Fesenko EE, Kolesnikov SS, Lyubarsky AL. Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment.

Rao A, Dallman R, Henderson S, Chen CK. Gbeta5 is required for normal light responses and morphology of retinal ON-bipolar cells. J Neurosci. 2007;27(51):14199–14204. 77. Berson DM, Dunn FA, Takao M. Phototransduction by retinal ganglion cells that set the circadian clock. Science. 2002;295(5557):1070–1073. 78. Xue T, Do MT, Riccio A, et al. Melanopsin signalling in mammalian iris and retina. Nature. 2011;479(7371):67–73. edu Contents 1. Introduction to Bone 2. 2 Introduction to RGS Proteins 3.

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RGS protein physiology and pathophysiology by Rory A. Fisher

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