By S.Z. Langer, A.M. Galzin and J. Costentin (Eds.)
The function of neuronal transporters within the inactivation of monoamine neurotransmitters and GABA following their free up from nerve terminals has been validated for a minimum of 30 years. it really is, notwithstanding, up to now 10 years that receptor binding ideas were used to label with excessive affinity the sodium-dependent transporter for serotonin and for this reason, that of different monoamine transmitters. This quantity experiences the massive advances within the box made because the first foreign Symposium on Presynaptic Receptors, and gives new insights into the functionality of presynaptic and neuronal transporters either within the outer edge and within the CNS, with their ubiquitous destinations and physiological roles. the 1st part offers with the broad and nonetheless expanding checklist of presynaptic release-modulating car- and heteroreceptors, and the several articles characterize the present state-of-the-art within the box of presynaptic modulation of neurotransmission. part is dedicated to the molecular pharmacology of presynaptic receptors, while part 3 covers fresh growth at the purification and molecular biology of transporter platforms
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Extra info for Presynaptic Receptors and Neuronal Transporters. Official Satellite Symposium to the IUPHAR 1990 Congress Held in Rouen, France, on 26–29 June 1990
Further experiments using more antagonists will evaluate the possibility of a receptor heterogeneity between both neuronal nicotine receptors. J. L. G. Marshall (1986). Prejunctional actions of cholinoceptor agonists and antagonists, and of anticholinesterase drugs. A. ), Vol. 79, pp. 141-170. Springer Verlag, Berlin, Heidelberg, New-York. Hobbiger, F. (1976). Pharmacology of anticholinesterase drugs. In: Handbook of Experimental Pharmacology (E. ), Vol. 42, pp. 486-581. Springer Verlag, Berlin, Heidelberg, New-York.
OBLIN, M. Z. LANGER (1990). 0418: a new alpha-2 antagonist with anti-hyperglycaemic properties. Eur. J. , 183,990-991. , H. SCHOEMAKER, I. ANGEL, S. ARBILLA, C. PIMOULE, A. GROSSET, G. PERRAULT, M. SEVRIN and A. WICK (1990). 0418: a new, potent and selective alpha-2 adrenoceptor antagonist with peripheral activity. Eur. J. , 183, 802. Does the Distance Between Nerve Varicosities and Adrenoceptors Play Any Role in the Relative Contribution of ATP/ Noradrenaline for Postjunctional Response? J. Gonçalves*, F.
Clonidine in concentrations which ranged from 10"9 M to 3 x 10~7 M inhibited the release of [3H]noradrenaline during electrical field stimulation of rat hippocampal slices. Maximum responses ranged between an inhibition of 68 and 85%. Treatment of rats with desipramine for 14 days caused a marked decrease in the sensitivity of presynaptic a2-adrenoceptors to clonidine. The clonidine concentration-effect curve was shifted downward with a marked decrease in the maximum inhibitory response (Fig. 2, graph A).
Presynaptic Receptors and Neuronal Transporters. Official Satellite Symposium to the IUPHAR 1990 Congress Held in Rouen, France, on 26–29 June 1990 by S.Z. Langer, A.M. Galzin and J. Costentin (Eds.)