By P. Schölmerich (auth.), Professor Dr. med. Hansjörg Just, Professor Dr. med. Hans Peter Schuster (eds.)
Primary myocardial affliction, these days known as congestive or, extra re cently, dilating cardiomyopathy, contains issues of various etiology. such a lot oftenly the pathogenetic mechanism or causative agent is still unknown. the importance of inflammatory strategies, i.e. myocarditis in a much broader experience because the etiologic issue has been debated for a few years. In a couple of circumstances, particularly in little ones and newborns viral infections may be incriminated. In adults this etiology may be ascertained merely in infrequent situations. And it has remained completely doubtful if, or below which conditions, and the way usually virus myocarditis can result in a prolonged affliction of the guts, particularly dilated cardiomyopathy. even though it would appear achieveable that an immunological reaction to an infectious agent may perhaps set off parenchymal harm with next lack of mobile functionality and structural integrity of everlasting nature, i.e. dilatation, sensible deterioration and dysrhythmias, quite a few makes an attempt to set up the sort of pathogenetic mechanism haven't but supplied convinicing effects. accordingly the reader will direct his recognition in particular to the respective contribution during this quantity. Morphologic reports have yielded a number of recent and fascinating findings in cardiomyopathy, yet have likewise did not settle the elemental query as to which etiology could be held dependable in a given case, particularly if an inflam matory approach may be incriminated. particular tactics reminiscent of sarcoidosis of the center definitely provide examples of persistent irritation as a reason behind dilating cardiomyopathy. This sickness, despite the fact that, as a particular inflammato ry myocardial affection, i.e. myocarditis, is encountered simply infrequently.
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Extra info for Myocarditis Cardiomyopathy: Selected Problems of Pathogenesis and Clinic
Whatever the reasons may be for lack of attention to it, small coronary disease is an important cause for myocardial degeneration and cardiomyopathy (James 1964, 1977a). As indicated earlier, there are certain infections which may involve the small coronary arteries (such as Whipple's disease), but this section will deal exclusively with noninfectious types of small coronary disease. Two forms of abnormalities of the small coronary arteries are those which are primarily or exclusively vascular (arterial) in nature, and those which have either minor or major nonvascular abnormalities associated with the small coronary disease.
Goodwin JF (1974) Prospects and predictions for the cardiomyopathies. Circulation 50:210 8. Helin M, SavoIa J, Lapinleimu K (1968) Cardiac manifestation during a Coxsackie B5 epidemic. Br Med J 3 :97 9. Kawai C, Matsumori A (1980) Myocardial biopsy. Annu Rev Med 31: 139 10. Kuhn H, Loogen F (1981) Erkrankungen des Myokards. In: KrayenbUhl P, KUbler W (eds) Kardiologie in Klinik und Praxis. Thieme, Stuttgart, p 48 11. Kuhn H, Breithardt G, Knieriem HJ, Loogen F, Booth A, Schmidt WAK, Stroobandt R, Gleichmann U (1975) Die Bedeutung der endomyokardialen Katheterbiopsie fUr die Diagnostik und die Beurteilung der Prognose der congestiven Kardiomyopathie.
Within the AV node (two arrows in B) of a patient dying of pheochromocytoma there is a focus of degeneration just beneath the upper arrow. The markedly narrowed A V node artery is seen at higher magnification in B, where the stain is Verhoeff-van Gieson. , .. /. , ,. / ,. -; . Fig. 21A, B. Platelet aggregation within small coronary arteries from two fatal cases of pheochromocytoma. The multiple aggregations in A are in a longitudinally sectioned artery and are recent, while the platelet aggregation in the fibrotic artery in B is older, since it is covered with a layer of fibrin and adheres to the wall of the artery.
Myocarditis Cardiomyopathy: Selected Problems of Pathogenesis and Clinic by P. Schölmerich (auth.), Professor Dr. med. Hansjörg Just, Professor Dr. med. Hans Peter Schuster (eds.)