Gary R. Lichtenstein's Medical Therapy of Ulcerative Colitis PDF

By Gary R. Lichtenstein

ISBN-10: 1493916769

ISBN-13: 9781493916764

ISBN-10: 1493916777

ISBN-13: 9781493916771

Medical remedy of Ulcerative Colitis will function a useful source for person physicians use who deal with sufferers with ulcerative colitis. The textual content offers a complete review of scientific treatment for administration of particular scientific situations and in addition a spotlight at the person medicines used to regard sufferers with ulcerative colitis. The publication can be proof dependent and concentrate on simplifying the present therapy to make it effortless to appreciate. The chapters are written through specialists of their fields and supply the freshest info. This publication will goal gastroenterologists who specialise in IBD, common gastroenterologists, fellows, and surgeons corresponding to colorectal surgeons or GI surgeons who may possibly deal with sufferers with ulcerative colitis.

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Extra resources for Medical Therapy of Ulcerative Colitis

Example text

These studies form the cornerstone of the prescribing and package insert information. Approximately 30 % of IND applications submitted to the FDA complete phase III studies [10]. Examples of phase III trials in UC include the ULTRA1 and ULTRA2 trials for adalimumab [11, 12] and ACT1 and ACT2 for infliximab [13]. Once a drug becomes FDA approved, it is actually the first time it is utilized and studied in patients who were not eligible for the original trials. This may include the elderly, children, women of childbearing age, and patients with significant comorbidities.

Sands BE, Abreu MT, Ferry GD, Griffiths AM, Hanauer SB, Isaacs KL, et al. Design issues and outcomes in IBD clinical trials. Inflamm Bowel Dis. 2005;11 Suppl 1:S22–8. 34. Travis S. Does it all ADA up? Adalimumab for ulcerative colitis. Gut. 2011;60(6):741–2. 35. Gardiner SJ, Gearry RB, Begg EJ, Zhang M, Barclay ML. Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold. Clin Gastroenterol Hepatol. 2008;6(6):654–60. quiz 04. 36. Kornbluth A, Sachar DB.

UC is characterized by chronic inflammation restricted to the colonic mucosa and traditionally involves contiguous areas of the colon without skip lesions with rectal involvement in most instances [3, 4]. However, rectal sparing and patchy colonic inflammation in patients with established diagnosis of UC are not uncommon during the disease course, especially following therapy [5–7]. In a study of 32 UC patients, Kim et al. found 38 % to have patchiness in their colon inflammation and 44 % to have rectal sparing based on endoscopic and histological evidence during their disease course; these changes were not related to any particular form of UC therapy [5].

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Medical Therapy of Ulcerative Colitis by Gary R. Lichtenstein


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