By Akhlaq A. Farooqui
Unless new discoveries are made within the prevention or remedy of stroke, Alzheimer's ailment and melancholy, the variety of sufferers with those illnesses is bound to extend dramatically by means of the yr 2050. hence, constructing options to retard or hold up the onset of stroke, advert and melancholy those neurological issues is of severe very important. the current monograph will supply present and entire info at the dating among neuroinflammation and oxidative tension in age-related neurological problems on the molecular point. the data defined during this monograph on way of life (diet and exercise), genes and age is meant to facilitate and advertise new discoveries for the therapy of age-related neurological disorders.
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Extra info for Inflammation and Oxidative Stress in Neurological Disorders: Effect of Lifestyle, Genes, and Age
Am J Physiol Endocrinol Metab 289:E429–E438 Björne HH, Petersson J, Phillipson M, Weitzberg E, Holm L, Lundberg JO (2004) Nitrite in saliva increases gastric mucosal blood flow and mucus thickness. J Clin Invest 113:106–114 Bonda DJ, Lee HG, Camins A, Pallas M, Casadesus G, Smith MA, Zhu X (2011) The sirtuin pathway in aging and Alzheimer disease: mechanistic and therapeutic considerations. Lancet Neurol 10:275–279 References 31 Bori Z, Zhao Z, Koltai E, Fatouros IG, Jamurtas AZ, Douroudos II, Terzis G, Chatzinikolaou A, Sovatzidis A, Draganidis D, Boldogh I, Radak Z (2012) The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle.
2001; Xie and Yung 2012). Sleep disturbance is a major cause of car and motorcycle accidents (Phillip and Akerstedt 2006). 12). Sleep is known to modulate the immune function by modulating the production of inflammatory cytokines through the involvement of Toll-like Receptors (TLRs), which are expressed on microglial cells and tissue-resident macrophages in the brain and visceral organs (Kim et al. 2011). Sleep deprivation induces the activation and translocation of NF-kB in specific brain regions associated with sleep regulation (Basheer et al.
1993), which may utimately lead to increase in cellular stress. ROS-mediated damage is ameliorated by a antioxidant systems acting at the cellular level to protect the integrity of biomolecules from oxidative damage (Bayir and Kagan 2008), Emerging evidences, both in in vitro and in vitro studies indicate that increase in ATP expenditure through calorie restriction exert beneficial effects on the brain primarily through improvement in antioxidant systems, upregulation of growth factors (BDNF, NGF, and IGF) and cytoprotective proteins, such as heat shock protein 72 (Hsp 72) (Hofer et al.
Inflammation and Oxidative Stress in Neurological Disorders: Effect of Lifestyle, Genes, and Age by Akhlaq A. Farooqui