By Shuji Terai, Takeshi Suda
This booklet studies the hot growth in gene and telephone remedy in the course of the liver and goals to facilitate a accomplished knowing of the present elements and destiny clients from uncomplicated study to medical remedies. Edited via pioneering researchers, this quantity offers wide details to significant investigators, researchers, postdocs and clinicians for analyzing the broad sorts of pathological stipulations either in and out the liver.
Providing not just the fundamental and medical points of treatment, this quantity is precise in that it specializes in the executive and regulatory problems of tangible medical program and criminal laws in several elements of the globe. by way of indicating the benefits and barriers of the main promising gene and phone treatments focusing on the liver, this e-book will encourage readers to strengthen a possible therapy within the subsequent generation.
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Extra resources for Gene Therapy and Cell Therapy Through the Liver: Current Aspects and Future Prospects
11. Harada N, Shimada M, Okano S, Suehiro T, Soejima Y, Tomita Y, et al. IL-12 gene therapy is an effective therapeutic strategy for hepatocellular carcinoma in immunosuppressed mice. J Immunol. 2004;173(11):6635–44. 12. Hirata M, Kita Y, Saito S, Nishimura M, Ito M, Mizuta K, et al. Increase in natural killer cell activity following living-related liver transplantation. Transpl Int. 1998;11 Suppl 1:S185–8. 13. Miller JS, Soignier Y, Panoskaltsis-Mortari A, McNearney SA, Yun GH, Fautsch SK, et al.
Tzakis Transplant Center, Cleveland Clinic Florida, Weston, FL, USA © Springer Japan 2016 S. Terai, T. 1 M. Ohira et al. Introduction Hepatocellular carcinoma (HCC) is one of the most common reasons for liver transplantation. However, HCC recurrence remains a serious issue after liver transplantation. The use of postoperative immunosuppression in the transplant recipient poses an additional risk for recurrence and hinders the use of cytotoxic chemotherapy drugs [1–4]. The major problem for HCC recurrence after liver transplantation is that no definitive treatment or prevention modalities exist [5, 6].
Burns LJ, Weisdorf DJ, DeFor TE, Vesole DH, Repka TL, Blazar BR, et al. IL-2-based immunotherapy after autologous transplantation for lymphoma and breast cancer induces immune activation and cytokine release: a phase I/II trial. Bone Marrow Transplant. 2003;32(2):177–86. 22. Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A, et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science. 2002;295(5562):2097–100. 23. Feng YX, Wang T, Deng YZ, Yang P, Li JJ, Guan DX, et al.
Gene Therapy and Cell Therapy Through the Liver: Current Aspects and Future Prospects by Shuji Terai, Takeshi Suda