By M. Wilkinson (auth.), Hans-Christoph Diener MD, Marcia Wilkinson MA, DM, FRCP (eds.)
M. WILKINSON sufferers with widespread or day-by-day complications pose a really tough challenge for the health care provider who has to regard them, fairly as many sufferers imagine that there might be a drugs or drugs which offer them quick aid. within the look for the compound which might meet this very typical hope, many medications were synthetic and the temptation for the medical professional is both to extend the dose of a drug which seems, at any expense, in part powerful, or so as to add a number of medicinal drugs to these which the sufferer is already taking. even supposing there were a few references to the hazards of overdosage of gear for migraine some time past, it was once no longer till rather lately that it used to be well-known that medicines given for the relaxation of headache, if taken injudiciously, may well themselves reason headache. the 1st medications to be implicated during this means have been ergotamine and phenazone. relating to ergotamine tartrate, the risks of ergotism have been popular as this was once a illness which were recognized and written approximately for a few years. within the remedy of headache, absolutely blown ergotism is unusual and in recent times has often been because of self-medication in doses a lot more than these prescribed even if there are a couple of recorded situations the place poisonous quantities were given.
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Additional info for Drug-Induced Headache
Here again codeine- and barbiturate-containing preparations took the lead. What Kind of Drugs Are Taken by Patients with Primary Headaches? 51 Table 10. 3 Other compounds, containing analgesics, barbiturates, and codeine • From the drugs mentioned, 173 were administered as tablets, five as dragees and 53 as suppositories. b n=615~100%. " Average dosage in tablets and dragees. Table 11. 3 Acetylicsalicylic acid Metamizole Paracetamol 500 500 500 a b All drugs given as tablets. More than one quotation possible.
Another line of evidence that DHE is able to induce or add to the induction of chronic headache can be deduced from our experience with DHE in migraine prophylaxis. 3. Dihydroergotamine intake per month. See Fig. 1 for explanation of symbols 5 mg 4 3 2 I 1 n=14 I 2 n=2 I 3 n=14 Fig. 4. Dihydroergotamine intake per day. See Fig. 1 for explanation of symbols 4 months and 5 mg per day for a further 3 months. Of these patients, 30% responded to therapy and showed a decrease in migraine frequency. The duration of concomitant headache (but not of migraine attacks), however, increased during long-term treatment.
Furthermore, they were questioned about the specific headache symptoms and whether or not changes in symptomatology had taken place in order to clarify when chronic daily headache had started. From their overall mean daily intake, we calculated the monthly and daily intake of chemically defined substances. Since most patients took tablets as w:ell as suppositories in varying amounts, we calculated the overall dosage without specifying the route of administration. We are well aware of the fact that the route of administration is important as the uptake is greater rectally than orally.
Drug-Induced Headache by M. Wilkinson (auth.), Hans-Christoph Diener MD, Marcia Wilkinson MA, DM, FRCP (eds.)