By Kieran Tuohy, Daniele Del Rio
Drawing on professional reviews from the fields of meals, intestine microbiology, mammalian body structure, and immunology, Diet-Microbe Interactions for Human Health investigates the proof for a unified affliction mechanism operating throughout the intestine and its resident microbiota, and linking many inflammation-related continual nutrition linked illnesses. state-of-the-art post-genomic reviews can spotlight the $64000 position performed by way of our resident intestinal microbiota in picking human healthiness and sickness. Many power human illnesses linked to glossy existence and diets — together with these localized to the intestinal tract like inflammatory bowel disorder and celiac affliction, and extra pervasive systemic stipulations akin to weight problems, diabetes and heart problems — are characterised by means of aberrant profiles of intestine micro organism or their metabolites. a lot of those ailments have an inflammatory foundation, frequently proposing with a protracted low-grade systemic irritation, hinting at chronic and irrelevant activation of inflammatory pathways. in the course of the presentation and research of contemporary foodstuff reviews, this booklet discusses the potential mechanisms underpinning the affliction tactics linked to those pathologies, with excessive fats diets showing to predispose to illness, and biologically lively plant elements, often fiber and polyphenols, showing to lessen the danger of power disorder development.
- One finished, translational resource for all facets of nutrients and diets impact on gastrointestinal overall healthiness and disease
- Experts in nutrients, vitamin, microbiology and immunology take readers from the bench learn (cellular and biochemical mechanisms of supplementations and food) to new preventive and healing approaches
- Clear shows through top researchers of the mobile mechanisms underlying nutrition, immune reaction, and gastrointestinal sickness aid training nutritionists and clinicians (gastroenterologists, endocrinologists) map out new components for scientific study and structuring medical recommendations
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Extra info for Diet-microbe interactions in the gut : effects on human health and disease
Establishing relevant links between the composition and activities of intestinal microbial populations and the host healthy phenotypes is a prerequisite of developing an effective probiotic intervention. 21 Substantial progress in acquiring knowledge about the microbial communities in the human gut has been recently enabled by culture-independent genomic studies based on microarray technologies and high-throughput sequencing. The study of the composition of the human colonic microbiota has long relied on culture-based analysis of fecal samples.
34 The introduction of solid food, by providing new substrates that may promote the survival and dominance of different species, evens out the differences between formula- and breast-fed babies. The phylogenetic diversity increases gradually over time, with Clostridium coccoides group and Bacteroidetes becoming predominant35,36 so that by the second year of life the microbiota profile resembles that of the adult. 39 Naturally delivered, exclusively breast-fed infants are characterized by a low incidence of morbidity and mortality, and immune-related disorders compared to babies who have experienced other modes of delivery and feeding.
Proc Natl Acad Sci USA. 2005;102:11070À11075. 40. Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444:1022À1023. 41. Turnbaugh PJ, Ley RE, Mahowald MA, et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444:1027À1031. 42. Dumas ME, Barton RH, Toye A, et al. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulinresistant mice. Proc Natl Acad Sci USA.
Diet-microbe interactions in the gut : effects on human health and disease by Kieran Tuohy, Daniele Del Rio