By Jacqueline A. Hubbard, Devin K. Binder
Epilepsy is a devastating workforce of neurological problems characterised by means of periodic and unpredictable seizure task within the brain. there's a severe want for brand new medicines and ways given than not less than one-third of all epilepsy sufferers usually are not made freed from seizures by means of latest medicines and develop into "medically refractory". a lot of epilepsy examine has fascinated about neuronal healing ambitions, yet present antiepileptic medications usually reason serious cognitive, developmental, and behavioral negative effects. contemporary findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure activity. in addition, many vital mobile and molecular alterations happen in astrocytes in epileptic tissue in either people and animal types of epilepsy. The aim of Astrocytes and Epilepsy is to comprehensively overview intriguing findings linking alterations in astrocytes to practical adjustments chargeable for epilepsy for the 1st time in e-book format. those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may possibly signify an immense new healing goal within the regulate of epilepsy.
Astrocytes and Epilepsy comprises heritage explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and facts from either human tissue reviews and animal versions linking practical adjustments in astrocytes to epilepsy. fantastically labelled diagrams are awarded and proper figures from the literature are reproduced to clarify key findings and ideas during this quickly rising field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking good care of sufferers with epilepsy.
- Presents the 1st finished publication to synthesize ancient and up to date learn on astrocytes and epilepsy into one coherent volume
- Provides an outstanding source at the box of astrocyte biology and astrocyte-neuron interactions
- Details strength healing objectives, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
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Extra resources for Astrocytes and Epilepsy
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Milton Brightman and Tom Reese identified structures connecting astrocytes (now known to be gap junctions) in 1969 . Nevertheless, glial cells were still thought to be passive participants in CNS function, playing a supportive role. However, in 1984 the research teams of Helmut Kettenmann and Harold Kimelberg identified glutamate and GABA receptors in astrocytes and oligodendrocytes [127–129]. In the 1980s, Glenn Hatton and colleagues showed that pituicytes (pituitary astrocytes) actively modulate hormone secretion, a direct glial–neuronal interaction in the neurohypophysis .
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Astrocytes and Epilepsy by Jacqueline A. Hubbard, Devin K. Binder