Download PDF by José Manuel Sánchez Ron: Albert Einstein (su vida, su obra y su mundo)

By José Manuel Sánchez Ron

ISBN-10: 8498929164

ISBN-13: 9788498929164

Considerado por l. a. revista Time en diciembre de 1999 como «el Personaje del siglo xx», Albert Einstein dejó una huella imborrable en l. a. historia de los angeles ciencia, con profundas implicaciones tanto en l. a. cultura como en el desarrollo sociopolítico de aquel siglo. Fue el gran protagonista de l. a. denominada «revolución relativista», que alteró de manera radical las principles que hasta entonces se sostenían sobre dos conceptos tan fundamentales como espacio y tiempo, y que culminó en l. a. que probablemente sea l. a. creación más unique de toda l. a. historia de los angeles ciencia, los angeles teoría de los angeles relatividad basic, que desbancó a l. a. vieja teoría de los angeles gravitación common de Isaac Newton. Y aunque finalmente repudió l. a. dirección que tomó, fue también uno de los responsables de que los angeles otra gran revolución de los angeles física del siglo xx, l. a. de los angeles física cuántica, se pusiera en marcha. En este libro, combinando el máximo rigor histórico con su acostumbrada claridad y elegancia expositiva, el catedrático de Historia de l. a. Ciencia y miembro de los angeles actual Academia Española, Sánchez Ron desentraña los angeles historia de los trabajos científicos de Einstein, que involucraron a una parte sustancial de los mejores físicos de l. a. primera mitad del siglo xx. Pero no se limita sólo al mundo de los angeles ciencia; al fin y al cabo, Einstein fue algo así como «un espejo del siglo xx», estando su vida indisolublemente asociada a los principales acontecimientos políticos y sociales de su tiempo (entre ellos las dos guerras mundiales), una dimensión de su biografía que, junto a los angeles de los avatares personales de su vida, explica el profesor Sánchez Ron, en un libro, profusamente ilustrado, que constituirá un hito en l. a. historia de los angeles ciencia, en cualquier idioma.

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2003; Huang et al. 2011; IARC 2009). The viral factors associated with oncogenic HPV-caused cervical cancer include the persistent infection, elevated viral load, HPV genotypes, and variants (Chen et al. 2011a, b; Chang et al. 2011; IARC 2009). Host factors include elder age, number of pregnancies, family history of cervical cancer, serum estrogen level, genetic polymorphisms of DNA repair enzymes, and human leukocyte antigen (Chen et al. 2011a; Chuang et al. 2012; IARC 2009). Environmental factors include tobacco smoking, immunosuppression, HIV-1 coinfection, use of oral contraceptives, and inadequate intake of micronutrients (IARC 2009).

Several pathogenic mechanisms are involved including oncogenic effects mediated by HBV proteins (such as HBx), by mutagenic insertion of parts of the viral DNA into the host cell genome, and by T cell-dependent autoimmunity (Farazi and DePinho 2006). A second virus that is significantly involved in the development of liver cancer is HCV, a single stranded RNA virus from the flavivirus family. HCV infection is a blood borne disease that chronically infects 3 % of the world’s population (Shepard et al.

01 % of cancer cells that enter the circulation will successfully develop micrometastases (Joyce and Pollard 2009). The initially increased motility and invasiveness of metastatic tumor cells are caused by the epithelial-mesenchymal transition (EMT). In the process of EMT, epithelial cells aquire a fibroblast-like properties that increase their motility and facilitates to invade epithelial barriers and to cross the basal membrane towards the circulation (Kalluri and Weinberg 2009). The extravasation of premetastatic cells is mediated by integrins, followed by crosstalk with immune and stromal cells, which allow them to proliferate (Polyak and Weinberg 2009).

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Albert Einstein (su vida, su obra y su mundo) by José Manuel Sánchez Ron


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